.immune-hero {
  background:
    radial-gradient(circle at 76% 24%, rgba(83, 225, 209, 0.14), transparent 31%),
    linear-gradient(135deg, #071a2b 0%, #0a3043 58%, #0b4148 100%);
}

.immune-module-tabs {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

.immune-icon {
  display: inline-flex;
  width: 30px;
  height: 30px;
  align-items: center;
  justify-content: center;
  border: 1px solid currentColor;
  border-radius: 50%;
  font-size: 14px;
  font-weight: 850;
  letter-spacing: 0;
}

.select-shell select:disabled {
  color: #778995;
  cursor: not-allowed;
}

.select-shell:has(select:disabled) {
  background: #eef3f5;
}

.hypothesis-line {
  margin-top: 7px !important;
  border-left: 2px solid #21bdb1;
  background: #eef8f6;
  color: #3f625f !important;
  padding: 8px 10px;
}

.immune-design-extension .extension-grid article {
  min-height: 200px;
}

.immune-design-extension .extension-grid strong {
  display: block;
  margin-top: auto;
  padding-top: 12px;
  color: #54717e;
  font-size: 9px;
  line-height: 1.55;
}

.planning-flow {
  scroll-margin-top: calc(var(--nav-height) + 24px);
  background:
    radial-gradient(circle at 8% 8%, rgba(49, 197, 184, 0.08), transparent 24%),
    #edf3f4;
  padding: 76px max(28px, calc((100vw - var(--content)) / 2));
}

.planning-flow-intro {
  max-width: 880px;
}

.planning-flow-nav {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 9px;
  margin-top: 30px;
}

.planning-flow-nav a {
  display: grid;
  grid-template-columns: auto minmax(0, 1fr);
  align-items: center;
  gap: 11px;
  min-width: 0;
  border: 1px solid #d3e2e5;
  border-radius: 11px;
  background: rgba(255, 255, 255, 0.76);
  color: #315064;
  padding: 13px 14px;
  text-decoration: none;
}

.planning-flow-nav a:hover,
.planning-flow-nav a:focus-visible {
  border-color: #70cfc6;
  background: #fff;
  outline: none;
}

.planning-flow-nav b {
  color: #0a9a92;
  font-size: 12px;
  font-variant-numeric: tabular-nums;
}

.planning-flow-nav span,
.planning-flow-nav small {
  display: block;
}

.planning-flow-nav span {
  font-size: 12px;
  font-weight: 850;
}

.planning-flow-nav small {
  margin-top: 3px;
  color: #7a8c96;
  font-size: 8px;
  font-weight: 650;
  line-height: 1.45;
}

.planning-step {
  scroll-margin-top: calc(var(--nav-height) + 28px);
  margin-top: 13px;
  overflow: hidden;
  border: 1px solid #d4e1e5;
  border-radius: 14px;
  background: rgba(255, 255, 255, 0.86);
  box-shadow: 0 10px 28px rgba(8, 52, 68, 0.035);
}

.planning-step > summary {
  display: grid;
  grid-template-columns: 50px minmax(0, 1fr) auto;
  align-items: center;
  gap: 16px;
  min-height: 94px;
  padding: 18px 22px;
  cursor: pointer;
  list-style: none;
}

.planning-step > summary::-webkit-details-marker,
.method-group > summary::-webkit-details-marker,
.atlas-group > summary::-webkit-details-marker,
.advanced-card-group > summary::-webkit-details-marker,
.supplement-panel > summary::-webkit-details-marker {
  display: none;
}

.planning-step > summary:hover,
.planning-step > summary:focus-visible {
  background: #f7fbfb;
  outline: none;
}

.planning-step[open] > summary {
  border-bottom: 1px solid #dce7ea;
  background: linear-gradient(90deg, #eff9f7, rgba(255, 255, 255, 0.96));
}

.planning-step-number {
  display: inline-flex;
  width: 42px;
  height: 42px;
  align-items: center;
  justify-content: center;
  border: 1px solid #b9dcd8;
  border-radius: 50%;
  background: #f2fbf9;
  color: #0a8e87;
  font-size: 12px;
  font-weight: 850;
  font-variant-numeric: tabular-nums;
}

.planning-step-copy,
.planning-step-copy small,
.planning-step-copy strong,
.planning-step-copy em {
  display: block;
  min-width: 0;
}

.planning-step-copy small {
  color: #0a9890;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.13em;
}

.planning-step-copy strong {
  margin-top: 5px;
  color: #17364a;
  font-size: 19px;
  line-height: 1.35;
}

.planning-step-copy em {
  margin-top: 5px;
  color: #6d808b;
  font-size: 10px;
  font-style: normal;
  line-height: 1.6;
}

.planning-step-count {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  border: 1px solid #d2dfe3;
  border-radius: 999px;
  background: #fff;
  color: #5e7480;
  padding: 6px 9px;
  font-size: 9px;
  font-weight: 800;
  white-space: nowrap;
}

.planning-step-count::after {
  content: "展开";
  border-left: 1px solid #dce5e8;
  color: #0a918a;
  padding-left: 8px;
}

.planning-step[open] .planning-step-count::after {
  content: "收起";
}

.planning-step-body {
  padding: 22px;
}

.research-atlas-grid {
  display: block;
}

.atlas-group {
  overflow: hidden;
  border: 1px solid #dbe6e9;
  border-radius: 11px;
  background: #fff;
}

.atlas-group + .atlas-group {
  margin-top: 10px;
}

.atlas-group > summary,
.advanced-card-group > summary,
.method-group > summary {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  align-items: center;
  gap: 16px;
  cursor: pointer;
  list-style: none;
}

.atlas-group > summary {
  padding: 14px 16px;
}

.atlas-group > summary:hover,
.atlas-group > summary:focus-visible,
.advanced-card-group > summary:hover,
.advanced-card-group > summary:focus-visible,
.method-group > summary:hover,
.method-group > summary:focus-visible {
  background: #f4faf9;
  outline: none;
}

.atlas-group[open] > summary,
.advanced-card-group[open] > summary,
.method-group[open] > summary {
  border-bottom: 1px solid #e0e8eb;
  background: #f4faf9;
}

.atlas-group-summary span,
.atlas-group-summary strong,
.atlas-group-summary small {
  display: block;
}

.atlas-group-summary span {
  color: #0a918a;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.1em;
}

.atlas-group-summary strong {
  margin-top: 4px;
  color: #26485a;
  font-size: 13px;
}

.atlas-group-summary small {
  margin-top: 4px;
  color: #758792;
  font-size: 9px;
  line-height: 1.5;
}

.atlas-group > summary > em,
.advanced-card-group > summary > em,
.method-group > summary > em {
  color: #0a8d86;
  font-size: 9px;
  font-style: normal;
  font-weight: 800;
  white-space: nowrap;
}

.research-atlas-card-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
  padding: 12px;
}

.research-atlas-grid article {
  border: 1px solid #d8e6e8;
  border-radius: 13px;
  background: rgba(255, 255, 255, 0.92);
  padding: 20px;
  box-shadow: 0 9px 24px rgba(9, 55, 72, 0.035);
}

.research-atlas-grid article > span {
  color: #0b938d;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.11em;
}

.research-atlas-grid h3 {
  margin: 10px 0 7px;
  color: #17384b;
  font-size: 16px;
  line-height: 1.45;
}

.research-atlas-grid p {
  margin: 0;
  color: #647b87;
  font-size: 10px;
  line-height: 1.75;
}

.research-atlas-grid article > div {
  display: flex;
  flex-wrap: wrap;
  gap: 7px;
  margin-top: 14px;
}

.research-atlas-grid button,
.vaccine-pattern-grid button {
  border: 1px solid #b8ddd8;
  border-radius: 999px;
  background: #effaf8;
  color: #087d77;
  padding: 6px 9px;
  cursor: pointer;
  font-size: 8px;
  font-weight: 800;
}

.research-atlas-grid button:hover,
.research-atlas-grid button:focus-visible,
.vaccine-pattern-grid button:hover,
.vaccine-pattern-grid button:focus-visible {
  border-color: #24b9ad;
  background: #e3f7f4;
  outline: none;
}

.vaccine-patterns,
.model-frontier {
  margin-top: 30px;
  border-top: 1px solid #d3e3e6;
  padding-top: 28px;
}

.section-intro.compact h3 {
  margin: 5px 0 0;
  color: #17384b;
  font-size: 22px;
}

.vaccine-pattern-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 230px), 1fr));
  gap: 10px;
  margin-top: 20px;
}

.vaccine-pattern-grid article {
  display: flex;
  min-height: 225px;
  flex-direction: column;
  border: 1px solid #dce7ea;
  border-radius: 11px;
  background: #fff;
  padding: 17px;
}

.vaccine-pattern-grid h4 {
  margin: 0 0 11px;
  color: #17364a;
  font-size: 14px;
  line-height: 1.45;
}

.vaccine-pattern-grid dl,
.vaccine-pattern-grid dd {
  margin: 0;
}

.vaccine-pattern-grid dl {
  display: grid;
  gap: 10px;
}

.vaccine-pattern-grid dt {
  color: #0a8d86;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.08em;
}

.vaccine-pattern-grid dd {
  margin-top: 4px;
  color: #637985;
  font-size: 9px;
  line-height: 1.7;
}

.vaccine-pattern-grid button {
  align-self: flex-start;
  margin-top: auto;
}

.model-frontier-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 210px), 1fr));
  gap: 9px;
  margin-top: 20px;
}

.model-frontier-grid article {
  border: 1px dashed #c8dadd;
  border-radius: 10px;
  background: rgba(247, 251, 251, 0.9);
  padding: 15px;
}

.model-frontier-grid span {
  color: #0b918a;
  font-size: 7px;
  font-weight: 850;
  letter-spacing: 0.1em;
}

.model-frontier-grid h4 {
  margin: 9px 0 6px;
  color: #244658;
  font-size: 12px;
  line-height: 1.4;
}

.model-frontier-grid p {
  margin: 0;
  color: #687e89;
  font-size: 9px;
  line-height: 1.7;
}

.immune-design-extension > .extension-grid {
  display: block;
}

.method-cards {
  margin-top: 0;
}

.method-group {
  overflow: hidden;
  border: 1px solid #d8e4e7;
  border-radius: 11px;
  background: #fff;
}

.method-group + .method-group {
  margin-top: 10px;
  border-top: 1px solid #d8e4e7;
  padding-top: 0;
}

.method-group > summary.method-group-heading {
  margin: 0;
  padding: 15px 16px;
}

.method-group-heading > div h3 {
  margin: 0;
  color: #17364a;
  font-size: 15px;
}

.method-group-heading > div span {
  display: block;
  margin-top: 4px;
  color: #72848f;
  font-size: 9px;
  line-height: 1.55;
}

.method-group-grid {
  padding: 12px;
}

#advanced-designs .design-extension {
  margin: 0;
  border: 0;
  background: transparent;
  padding: 0;
}

#advanced-designs .outcome-map {
  margin-top: 0;
  margin-bottom: 20px;
}

#advanced-designs .extension-heading {
  padding: 4px 2px 0;
}

.advanced-card-group + .advanced-card-group {
  margin-top: 10px;
  border-top: 1px solid #d8e5e7;
  padding-top: 0;
}

.advanced-card-group {
  overflow: hidden;
  border: 1px solid #d8e5e7;
  border-radius: 11px;
  background: #fff;
}

.advanced-card-group > summary {
  padding: 15px 16px;
}

.advanced-card-group-heading span,
.advanced-card-group-heading strong,
.advanced-card-group-heading small {
  display: block;
}

.advanced-card-group-heading span {
  color: #0a918a;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.1em;
}

.advanced-card-group-heading strong {
  margin-top: 4px;
  color: #244658;
  font-size: 13px;
}

.advanced-card-group-heading small {
  margin-top: 4px;
  color: #758792;
  font-size: 9px;
  line-height: 1.5;
}

.advanced-card-group-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(min(100%, 215px), 1fr));
  gap: 10px;
  padding: 12px;
}

.immune-design-extension .advanced-card-group-grid article {
  display: flex;
  min-height: 205px;
  flex-direction: column;
}

.immune-design-extension .advanced-card-group-grid .extension-actions {
  margin-top: auto;
  padding-top: 12px;
}

.immune-design-extension .advanced-field small {
  min-height: 0;
}

.immune-design-extension .advanced-result-panel {
  min-width: 0;
}

#vaccine-patterns-step .vaccine-patterns {
  margin: 0;
  border-top: 0;
  padding-top: 0;
}

.model-frontier.supplement-panel {
  margin-top: 18px;
  overflow: hidden;
  border: 1px solid #d4e2e5;
  border-radius: 11px;
  background: #f8fbfb;
  padding: 0;
}

.supplement-panel > summary {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 16px;
  padding: 15px 16px;
  cursor: pointer;
  list-style: none;
}

.supplement-panel > summary:hover,
.supplement-panel > summary:focus-visible,
.supplement-panel[open] > summary {
  background: #f0f8f7;
  outline: none;
}

.supplement-panel[open] > summary {
  border-bottom: 1px solid #dce6e9;
}

.supplement-panel > summary span,
.supplement-panel > summary small,
.supplement-panel > summary strong {
  display: block;
}

.supplement-panel > summary small {
  color: #0a918a;
  font-size: 8px;
  font-weight: 850;
  letter-spacing: 0.1em;
}

.supplement-panel > summary strong {
  margin-top: 4px;
  color: #244658;
  font-size: 13px;
}

.supplement-panel > summary em {
  color: #657b88;
  font-size: 9px;
  font-style: normal;
  font-weight: 800;
  white-space: nowrap;
}

.supplement-panel .model-frontier-grid {
  margin-top: 0;
  padding: 12px;
}

.simulation-diagnostics h5,
.advanced-sensitivity h5 {
  margin: 0 0 9px;
  color: #29495b;
  font-size: 11px;
}

.simulation-diagnostics .advanced-simulation-summary {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 8px;
  margin: 0;
  border: 1px solid #dce7ea;
  border-radius: 9px;
  padding: 13px;
}

.simulation-diagnostics .advanced-simulation-summary div {
  min-width: 0;
}

.simulation-diagnostics dt {
  color: #6b7e89;
  font-size: 8px;
}

.simulation-diagnostics dd {
  margin: 3px 0 0;
  overflow-wrap: anywhere;
  color: #244b5b;
  font-size: 9px;
  font-weight: 750;
}

.advanced-method-detail {
  margin-top: 10px;
  overflow: hidden;
  border: 1px solid #dbe6e9;
  border-radius: 9px;
}

.advanced-method-detail summary {
  color: #315064;
  padding: 12px 13px;
  cursor: pointer;
  font-size: 9px;
  font-weight: 850;
}

.advanced-method-detail > div {
  border-top: 1px solid #e1e9eb;
  padding: 13px;
  color: #526d79;
  font-size: 9px;
  line-height: 1.7;
}

.advanced-method-detail h5 {
  margin: 12px 0 4px;
  color: #29495b;
}

.advanced-method-detail h5:first-child {
  margin-top: 0;
}

.advanced-method-detail code {
  display: block;
  overflow-wrap: anywhere;
  border-radius: 6px;
  background: #eef5f6;
  padding: 9px;
}

.metric-grid b {
  overflow: visible;
  overflow-wrap: anywhere;
  text-overflow: initial;
}

@media (max-width: 760px) {
  .immune-module-tabs {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }

  .immune-module-tabs .module-icon {
    display: none;
  }

  .planning-flow {
    padding: 56px 18px;
  }

  .planning-flow-nav {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .planning-step > summary {
    grid-template-columns: 40px minmax(0, 1fr);
    gap: 11px;
    min-height: 0;
    padding: 15px;
  }

  .planning-step-number {
    width: 36px;
    height: 36px;
    font-size: 10px;
  }

  .planning-step-copy strong {
    font-size: 16px;
  }

  .planning-step-copy em {
    font-size: 9px;
  }

  .planning-step-count {
    grid-column: 2;
    justify-self: start;
  }

  .planning-step-body {
    padding: 13px;
  }

  .research-atlas-card-grid {
    grid-template-columns: 1fr;
  }

  .research-atlas-grid article {
    padding: 17px;
  }

  .vaccine-pattern-grid article,
  .immune-design-extension .advanced-card-group-grid article {
    min-height: auto;
  }

  .atlas-group > summary,
  .advanced-card-group > summary,
  .method-group > summary {
    grid-template-columns: 1fr;
    gap: 7px;
  }

  .atlas-group > summary > em,
  .advanced-card-group > summary > em,
  .method-group > summary > em {
    justify-self: start;
  }

  .simulation-diagnostics .advanced-simulation-summary {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 480px) {
  .planning-flow-nav {
    grid-template-columns: 1fr;
  }

  .planning-flow-nav a {
    padding: 11px 12px;
  }

  .supplement-panel > summary {
    align-items: flex-start;
    flex-direction: column;
  }
}

@media print {
  .print-report .report-assumption {
    break-inside: avoid;
  }
}